Celiac profile by genova Diagnostics
aids in determining the presence of
Celiac disease. Celiac Disesase is
defined as a genetic, immune mediated
enteropathy of the small bowel that
results in malabsorption. The disease
is characterized by sensitivity to
the proteins found in wheat, and to
a lesser extent, barley and rye. The
National Institutes of Health reported
in August of 2004 that the prevalence
of Celiac Disease is much greater than
previous estimates, possibly affecting
as many as 3 million Americans, indicating
that the disease is widely under recognized.
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Who should be tested for Celiac Disease?
The clinical presentation of celiac disease
has many faces and, as a consequence, the disease is often misdiagnosed.
In fact, the average time from disease to diagnosis is 11 years.
Those afflicted may have classic gastrointestinal (GI) symptoms
or may only exhibit extra-intestinal manifestations.
The Celiac & Gluten Sensitivity test tests a patients blood for total IgA as well as IgA specific antibodies for possible celiac disease or gluten sensitivity. Celiac disease, also known as celiac sprue or gluten sensitivity enteropathy, is a chronic autoimmune disease which has a genetic component and may affect several family members. Celiac is a lifelong condition with no cure however, it is manageable once diagnosed.
What is celiac disease?
Celiac disease is a digestive condition triggered by consumption of the protein gluten, which is found in bread, pasta, cookies, pizza crust, and many other foods containing wheat, barley, or rye. When a person with celiac disease eats food containing gluten, an immune reaction occurs in the small intestine, resulting in damage to the surface of the small intestine and an inability to absorb certain nutrients from food.
Conditions, diseases, and symptoms related to Celiac Disease:
- Abdominal cramps, gas, and bloating
- Crohns disease
- Foul-smelling or grayish stools that may be fatty or oily
- Gastric ulcers
- General weakness
- Intermittent diarrhea
- Irritable Bowel Syndrome (IBS)
- Parasitic infections
- Skin disorders
- Stunted growth (in children)
- Weight loss
- Lupus erythematosus
- Type 1 diabetes
- Rheumatoid arthritis
- Autoimmune thyroid disease
- Microscopic colitis
in absence of overt GI complaints, avoidance of gluten is imperative
owing to the risk of lymphoma and other malignancies associated
with celiac disease. Clinicians should therefore consider routine
screening for patients with the following clinical indications:
Unexplained weight loss
Atypical Celiac Indications
Type 1 diabetes
Irritable bowel syndrome
high risk groups include: first degree relatives, siblings and those
with Immunoglobulin A (IgA) deficiency.
Patients with celiac disease are 10-15 times more likely to have
IgA deficiency. Testing for total IgA increases the diagnostic accuracy
by ruling out false negative results in this cohort. IgA-tTG (Anti-Tissue
Transglutaminase) and IgG-tTG enzymes are highly sensitive markers
for identifying celiac disease. When IgA-tTG is positive, testing
for IgA-Anti-endomysial Antibodies (IgA-EMA) is routinely performed.
This further enhances the accuracy of the profile, and helps identify
those with silent and latent forms of the disease.
Clinicians also have the option of testing two additional analytes;
- IgA Anti-gliadin Antibodies (IgA-AGA)
- IgG Anti-gliadin antibodies (IgG-AGA)
These antibodies can be performed as part of the initial diagnostic
evaluation, or on their own to monitor compliance to a gluten free
set up a nutritional consultation so that tests can be performed and
a comprehensive strategy of lifestyle, dietary modification and nutrient
supplementation can be implemented to aid you in reversing this disorder.
Treatment requires life-long abstinence of gluten containing foods.
With the need for such a restrictive diet, it is important to accurately
determine who has the condition. The Celiac Profile from Genova
Diagnostics incorporates the most advanced non-invasive markers
along with traditional serological tests.
For an appointment, contact our office at: 800-956-7083 or 818 707-3126.
Dr. Rispoli, Ph.D., L. Ac. has had a clinical practice for over 20
years. Her programs work because she is so thorough in testing and
providing a nutritional approach. Remember that the body can heal
itself if given the proper nutrients.