prevalence of gastrointestinal complaints
in general practice is rather impressive.
Although many of these complaints
are vague, the longterm clinical
consequences of untreated complaints
seems to be impaired assimilation
with reduced regenerative capacity
and in-creased rate of aging. The
causes of these complaints are ferreted
out and investigated in the GI Health
Panels.™ The GI Health
Panel™ by Diagnos Tech intended
to evaluate gastrointestinal function
and health non-invasively.
order this test click the
panel employs three stool and two saliva
specimens to determine:
Causes of Gastrointestinal Dysfunction
Pathogen associated GI complaints caused by:
Normal Flora Imbalances
Neuroenteric related complaints (not part of panel) caused by:
Dystonia of GI smooth muscle
Dysrhythmia of GI smooth muscle
Sympathetic to parasympathetic imbalance
Non pathogen related GI complaints caused by:
Acquired or genetically determined functional and structural GI
Dietary intolerances & allergies
Use the GI Panels™ to increase diagnostic accuracy & therapeutic
The pathogen associated aspect of GI complaints is gaining increased
recognition as evidenced by the U.S. based statistics shown below.
More recently, several zoopathogens have emerged as threats to human
health, including Cryptosporidium, Cyclospora, Babesia, Borrelia,
Table 1. Parasite
Clostridium difficile 5% of Population or 13 million people
Giardia lamblia 7.2% Population Extrapolated- 19 million
Entamoeba coli 4.2% Population Extrapolated- 11 million
Endolimax nana 4.2% Population Extrapolated- 11 million
Toxoplasma gondii 50-60% Population Extrapolated- 110 million
Blastocystis hominis 2.6% Population Extrapolated- 7 million
For Better Detection of Parasites & Food Intolerance
The roundworm ascaris lumbricoides is the most common worm infection
worldwide. It is more concentrated in warm, moist climates (southeastern
U.S.) and on swine farms or where pig feces are used as fertilizer.
Humans acquire it by swallowing eggs from contaminated soil, water,
fruits or vegetables and in children through the fecal-oral route.
Clinically, it causes coughing and difficulty breathing that subsides
only to be followed by abdominal discomfort / pain. A common finding
is malnutrition, especially in children. Microscopic egg detection
is elusive because the time required from egg ingestion to shedding
in stool is 2-3 months. The saliva based SIgA test enhances detection
of this worm.
Tissue worm Detection:
Trichinella spiralis is a tissue worm of swine. Humans acquire the
infection by ingesting the larvae from undercooked pork. The parasite
re-sides mainly in skeletal muscle causing long standing inflammation
and fibromyalgia. With poor meat handling and cooking habits this
infection is becoming more widespread. Saliva SIgA detection is
used as the basis of our trichinella detection.
A chronic tissue parasite infestation, affecting 50-60% of the U.S.
Population. It is mostly acquired from contact with cat litter,
secretions and the consumption of undercooked meat. This organism
forms cysts in human tissue, including the brain and muscle. Immune
suppression can lead to the release of the active tachyzoites from
the cysts causing symptomatic exacerbations. Asymptomatic individuals
may experience a gradual decline in memory and cognitive abilities.
Saliva samples are used to detect toxoplasma secretory antibodies.
Swine tapeworm (Taenia solium) infections are worldwide and concentrated
in countries where pork is consumed and sanitation is poor. The
human harbors the adult worm which is 6-20 feet long and inhabits
the small intestine. The head is armed with about 22-32 hooks and
the worm sheds 250,000 or more eggs a day. When the pig consumes
the eggs from human feces (ex. sewage fertilizer), the eggs partially
mature into the intermediate form, the cysticercus, which infects
the muscle and brains of swine. Humans consuming infected undercooked
pork, or eating food contaminated with infested human feces can
develop intestinal tapeworm and/or tissue migrating tapeworm Larvae
(cysticercosis). Muscles and the brain are a favorite site of larval
hatching. Myositis, fibromyalgia and CNS related problems are common
clinical manifestations. Saliva SIgA is used for detection.
Food Intolerance Testing:
Analyzes the antigen specific Secretory IgA in saliva to detect
genetically inherited food intolerances to Wheat (gluten), Cow's
milk (casein), Eggs (ovalbumin) and Soy protein. These predisposed
individuals usually experience intestinal inflammation after consumption
of the offending foods. Subsequently, the intestinal mucosa releases
Secretory IgA to neutralize the antigens. SIgA testing, unlike IgG,
allows detection of mild, subclinical, and latent intolerance cases.
Furthermore, the short SIgA half-life insures earlier and more effective
compliance/follow up assessments.
Case Study One (Missed Diagnosis)
Patient had mild discomfort in left abdomen with some irregular
bowel movements. Patient had a stool exam at another laboratory.
Results showed normal values with a so called mild "dysbiosis."
Patient was treated with herbs and lactobacilli, six months later
patient consults another physician for same problem. A GI Health
Panel™ was ordered from Diagnos-Techs.
Elevated Lysozyme - Colon inflammation marker
Occult blood - Positive
Our laboratory recommended endoscopy due to lysozyme increase. Patient
had a colonic tumor (CA) the size of an orange. Surgery was required.
Case Study Two (Wrong Diagnosis)
A 28 year old male had mild abdominal discomfort and fragmented
stools. Patient had a stool analysis at another laboratory which
showed alleged "dysbiosis" with some citrobacter spp.
and reduced content of short chain fatty (SCF) acids in stool. He
was treated with antibiotics over six years and still had symptoms
in spite of citrobacter elimination. The SCF acids reverted to normal.
Patient sought help at another clinic. A GI Health Panel™
with a transit retention time capsule was ordered.
Clostridium Antigen positive
A reduced transit time of 8 hours, normally 20-28 hours
C. difficile was treated with tinidazole for 7 days. Transit time
was normalized with 1/3 tablet Loperamide. Elevated ACHY which indicated
small intestine irritation was rectified using a gooseberry paste
(AmlaPaste™) for 30 days. Follow up - all parameters within
range and no symptoms.
The GI Health Panel™ is worth considering for:
Inflammatory bowel disease
Chronic loose stool or constipation
Fat, grain, and food intolerance
School & pool associated GI problems
Chronic abdominal discomfort/pain
Chronic fatigue and fibromyalgia
Excessive eating pattern/Anorexia
Post travel loose stool/diarrhea
Sudden changes in bowel habits
Bloating, maldigestion, heartburn
Excess gas and flatulence
Chronic skin conditions
Poor sleeping habits
GI Health Panel™ & Expanded GI Health Panel™
Food Intolerance (saliva)
Parasite Tests (saliva)
Parasite Tests (stool)
O&P Microscopy (stool)
+We report all visualized parasites.
Functional Markers (stool)
Alpha Anti-chymotrypsin (ACHY)
Pathogen & flora cultures
*In Expanded GI Health Panel™ only.
Why choose Diagnos-Techs?
Our 15 to 22 parameter GI Health Panels™ are the most logical,
complete and economical profiles offered anywhere in the nation.
Our integrated approach using 22 conjoint parameters allows diagnostic
investigation of infectious-parasitic, inflammatory, digestive,
immune and dietary related causes of GI complaints. Multi-faceted
Interpretive Support: DTI provides you with a concise GI knowledge
base presented in the form of a monograph. In addition, our medical
and technical staff are available for patient-specific interpretation
Some GI test
comparisons- Diagnos-Techs vs the Competition
Some parasites are elusive by nature (organism fragmented in stool
sample; only intracellular presence; not in shedding phase…)
making them impossible to visualize even with advanced staining
techniques. DTI circumvents these limitations by assem-bling a slate
of parasitic antigen and antibody detection tests (Giardia, Toxoplasma,
Ameba, Ascaris, Cryptosporidium, Trichinella, Tapeworm etc.).
The competition offers you a purge which, besides its traumatic
effects on patients, will burst many parasites precluding the ability
to visualize them microscopically. Many companies use immunofluorescence
slide visualization for parasite detection which requires presence
of intact organisms. Many parasites are missed by only using microscopic
TRICHINELLA, ASCARIS & TAPEWORM:
New DTI tests that widen your perspective on chronic illnesses and
The competition does not test for these parasites.
Note: Tissue parasites are not self-limiting & will persist
indefinitely without treatment.
MICROFLORA EVALUATION/PATHOGEN DETECTION:
The colonic microflora is comprised of over 500 species of bacteria.
DTI globally assesses the normal gut flora and will speciate the
overgrowth / pathogenic bacteria and yeast.
Our panels routinely include reflex sensitivity testing for relevant
bacterial pathogens. DTI dropped all yeast sensitivity testing a
long time ago due to lack of correlation with clinical efficacy
Other laboratories presume that a partial non-quantitative evaluation
of 1-2% of the microflora species, allows them to make general statements
such as "Dysbiosis". This unscientific reporting ignores
the important quantitative relationships between the climax communities
and underestimates the role of a majority of non tested species.
In vitro yeast sensitivity testing does not correlate with clinical
efficacy of antimicro-bials tested. A natural / herbal product may
show inhibition to specific yeast in a Petri dish at a certain concentration.
However, this does not imply that the ingested herb will achieve
comparable concentrations in the actual tissue sites infected by
tests for the constitutional intolerances
to grain, soy, egg and milk proteins
using antigen-specific Secretory IgA.
Intolerant patients experience a toxic
reaction when the food in question
is consumed. This reaction will trigger
an inflammatory / immune response leading
to SIgA production. SIgA, unlike IgG,
has a short memory of several weeks,
allowing you to monitor compliance
within 60 days of treatment.
Other labs do not include food intolerance tests in their GI panels.
IgG is an invalid way of testing for food intolerance; the fact
that a patient has a positive response to a food item does not mean
that there is an accompanying GI reaction or toxicity. Many patients
show an IgG response to foods they have never eaten or come into
contact within their lifetime. Clinically, patients may not experience
any difference after avoiding the foods in question.
DTI tests for Chymotrypsin, a reliable
marker for all digestive enzymes from
the pancreas. We also test for occult
blood and fecal pH. We do not quantitate
any short chain fatty acids (SCFA)
SCFA'S are end-products of bacterial fermentation of dietary fiber.
The relative SCFA stool composition depends on diet choice, transit
time, and the actual gut flora of a specific individual. Published
papers show that random stool SCFA is a poor marker of GI health
or colonic cancer risk.
MUCOSAL IMMUNITY & OTHER MARKERS:
DTI's panel includes parameters
of mucosal immunity, colonic inflammation
and small intestinal irritation
which help diagnose and localize
the site of GI problems (colon
vs. small intestine). The panel
results allow you to detect insults
to the gut.
Other labs do not offer any gut immunity and inflammation markers.
The leaky gut test they offer is only symptom/condition detection
without examining the causative factors that include inflammation,
foreign organisms, offensive foods…. DTI avoids diagnosing
a symptom without reporting on the causes.