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Intestinal Antigenic Permeability Screen Array 2 /Serum $290
Includes Reoprt of Findings
Intestinal Antigenic Permeability Screen Array 2 by Cyrex Labs

CLINICAL USE:

• Measure intestinal permeability to large molecule which inflame the immune system
• Identify the damaging route through the intestinal barrier

RECOMMENDED FOR PATIENTS WHO:

• Present multiple symptom complaints(including Chronic Fatigue Syndrome)
• Suffer from abnormal immune cell count and function (including autoimmune diseases)
• Complain of food allergy and intolerance


Intestinal Antigenic Permeability Screen Array 2 $290



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Leaky Gut Progression
MEASURING INTESTINAL PERMEABILITY

Two decades ago, the assessment of Intestinal Permeability was done by measuring the leakage of a sugar molecule (lactulose) into the blood dtream. Since then, numerous studies have questioned the clinical relevance of this marker. IT is not measuring antigenic macromolecule passage, because passage of very small molecules such as sugar, lacks a capacity to challenge the immune system. Therefore, measurements of intestinal permeability to antigenic molecules are assessed not only against the triggers of intestinal barrier degradation such as bacterial endotoxins, but also against barrier structures occulin/zonulin and actomyosin, which represents both paracellular and transcellular pathways.

Therefore, macromolecular intestinal permeability, which stimulates an immune response, can be accurately measured by identifying either antibodies to antigenic molecules, which trigger intestinal barrier degradation such as bacterial endotoxins, or antibodies against the componets involved in the intestinal barrier degradation such as occudin/zonulin and actomyosin.

Elevated antibodies to LPS, (Lipopolysaccharides), Occuludin/Zonulin and the Actomyosin Network are patent pending biomarkers that identigy the breakdown of a healthy intestinal barrier, which allow penetration of large antigenic molecules.

1. LPS (Lipopolysaccharides) are large molecules found in gram-negative bacteria. They are endotoxins,mand if absorbed, elicit a strong immune response. The dection of antibodies against LPS reveals macromolecule-sized endotoxin infiltration through the intestinal barrier into the systemic circulation.

2. Occulin is part of the main component of proteins holding together the tight junctions. The detection of antibodies to occludin indicates that the tight junctions are breaking down. This is a measure of a mecanism involved in damaging the intestinal membrane.

3. Zonulin, a protein regulates the permeability of the intestine. The detection of antibodies against zonulin indicates that the normalregulation of tight junctions is compromised. This can be a clue to presence of an ongoing mechanism involved in damaging the inttestinal barier.

4. The Actomyosin Network, a protein complex, regulates intestinal barrier function by maintaining the plasticity of tight junctions. Antibodies to the actomyosyn network are a biomarker of intestinal barrier dysregulation via cell infiltration. For example,m 98.2% of Celiac disease patients with flat mucosa have antibodies to actin. This is a measure of mechanism involved in damaging the intestinal barrier.

Antibody Array 2 for assessment of intestinal barrier integrity measures antibodies against bacterial endotoxins (lipopolusaccharides), tight-junction proteins (occuluin, zonulin) and cell cytoskeleton (actomyosin), and identifies both transcellular and paracellular routes of intestinal penetration by large molecules with a capacity to challenge the immune system.

Gluten Protein

All lab tests can be done through the mail in the privacy of your own home, except blood tests, we send you to a lab to have your blood drawn for these. After you pay for the test we mail you the kit, the results take two weeks, the test results will be mailed to us and we will call you to go over the results, its that easy! All tests include the consultation for the report of findings.

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Call our office for details. 
800-956-7083 OR 818-707-3126