|This testby Genova Diagnositcs utilizes a urine sample in order to evaluate the body's oxidative stress status and antoxidant reserve. It can help practitioners identify underlying causes and perpetuating factors for many clinical disorders and to customize specific treatment programs. Especially
useful in cases of chronic fatigue, xenobiotic exposure, and chronic
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Oxidative stress at the cellular level
results from many factors, including exposure to alcohol, medications,
trauma, cold, toxins or radiation. Although the biochemical significance
of oxidative stress has been proven in relation to a vast range of
degenerative disorders, including cancer, diabetes, premature aging,
Alzheimer's and many others, until recently it has been difficult
to assess its impact upon individuals and then measure effectiveness
of therapeutic intervention.
Laboratory's Oxidative Stress Profile
is a sensitive assessment utilizing
challenge substances to evaluate
the bodys' oxidative stress status,
antioxidant reserve and interrelationship
with liver detoxification. This
test provides a powerful window
on the status of the body's intra-cellular
health, and allows clinicians
to develop individual therapies
for patients and monitor treatment
Free Radicals & Antioxidants
In the course of normal human activity – energy production, detoxification of pollutants and immunologic defense mechanisms, free radicals are produced. These free radicals are unstable molecules that can extract an electron from a neighboring molecule, causing damage in the process. Unchecked free radical production accelerates the pathogenesis of human disease and aging. These free radicals are counter-balanced by the anti-oxidants present in our foods (and supplements).
Dietary antioxidants (such as proanthocyanidins found in blueberries and bioflavonoids found in citrus fruits), as well as the antioxidant enzymes, superoxide dismutase and glutathione peroxidase, provide critical protection against free radical damage. Oxidative stress results when this delicate prooxidant/ antioxidant equilibrium is disrupted in favor of the pro-oxidant (free radical) state.
Evidence is accumulating that oxidative stress is involved in many pathological processes, including:
- Rheumatoid arthritis
- Diabetes mellitus
- Macular degeneration
- Chronic Fatigue Syndrome
- Inflammatory Bowel Disease
- Environmental sensitivity
- Neurodegenerative diseases such as Parkinson’s and Alzheimer’s
In a chain-like reaction, free radicals can cause cellular damage by oxidizing nucleic acids, proteins, and membrane lipids. Cellular mitochondria play an important role in aging and disease by being both a significant source of radicals and a primary site of free radical damage. Antioxidants blunt the production of compounds that create inflammation in the body.
Oxidative Stress Testing
To assess equilibrium between oxidative damage and antioxidant reserve, it is necessary to address the RESERVE capacity that provides protection; the ENZYMES that quench the free radicals; and evaluate the DAMAGE that free radical production has already caused.
- A blood sample measures anti-oxidant reserve and enzyme function including: whole blood Glutathione, Total Antioxidant Capacity, and the enzymes Superoxide Dismutase and Glutathione Peroxidase. Additionally, blood markers of damage measure lipid peroxides (oxidative damage to cell membranes).
- A urine sample to measure free radical damage, including lipid peroxides (oxidative damage to cell membranes) and 8-hydroxy-deoxyGuanosine (oxidative damage to DNA).
All lab tests can be done through the mail in the privacy of your
own home, except blood tests, we send you to a lab to have your
blood drawn for these. After you pay for the test we mail you the
kit, the results take two weeks, the test results will be mailed
to us and we will call you to go over the results, its that easy!
All tests include the consultation for the report of findings.
Click on test of interest on the right for more information
Call our office for details.
800-956-7083 OR 818-707-3126