unhealthy blood sugar metabolism can significantly affect the health
of your nerves, eyes, blood vessels, kidneys and pancreas. It can
impact your weight, body shape, energy levels, blood pressure, cholesterol,
triglyceride's, overall cardiovascular health and more. Over 60 million
Americans have "insulin resistance," a form of unhealthy
blood sugar metabolism that frequently goes unrecognized and can
progress to the point where signs of significant health deterioration
let this happen to you! It is never too late to learn how you can
achieve and maintain healthy blood sugar metabolism and experience
the benefits of sustained good health.
Lifestyle and Healthy Blood Sugar Metabolism
diet, obesity and lack of exercise are considered major contributors
to developing poor blood sugar metabolism. Incorporating lifestyle
changes that focus of effective weight control, healthy eating habits
and a program of regular exercise are very important to promoting
healthy blood sugar metabolism.
That Lead to Unhealthy Blood Sugar Metabolism
time, inactivity and an unhealthy diet can lead to unhealthy sugar
metabolism. When we consume excess sweets and refined or processed
foods the simple sugars they contain are absorbed very quickly and
can cause a rapid and dramatic increase in our blood sugar levels.
With a high concentration of sugar in the blood, the pancreas responds
by producing a proportionally high surge of insulin in an effort
to help the sugar gain entrance into the cell. In unhealthy blood
sugar metabolism, the cell may be unresponsive or"insulin resistant"
and sugar delivery into the cell can be reduced. The pancreas then
tries to compensate by producing even more insulin. Over time these
high levels of insulin can lead to a host of problems, including
increased triglyceride's levels, decreased HDL (good) cholesterol
levels, high blood pressure, cardiovascular manifestations and hormone
"insulin resistance" may occur because, along with excess
sweets and refined carbohydrates, an unhealthy diet is also frequently
deficient in the nutrients necessary to support healthy cell membranes,
insulin receptors and a strong insulin signal. Unhealthy insulin
receptors can result in poor binding of insulin and, in concert
with other factors, a diminished insulin signal, thereby, reducing
sugar delivery into the cell. These other factors include the negative
effects of specific enzymes and cytokine's, such as phosphotyrosine
phosphatase, nuclear factor-kappaB (NK-kappaB), and tumor necrosis
factor alpha (TNF-alpha).
unhealthy diet may even alter the way the genetic information within
our cells influence blood sugar metabolism. Scientists now know
that a poor diet, along with other contributors, can alter our genetic
potential or gene expression. Appropriate gene expression is important
for healthy blood sugar metabolism because it stimulates sugar utilization
by the mitochondria of the cells, producing energy and, in effect,
clearing sugar from the blood.
as a whole, excess weight, lack of exercise and an unhealthy diet
can reduce the "sensitivity" of your cells to insulin
and even impact their gene expression. Without effective insulin
binding and signaling, the sugar transport channel vesicles remain
static and unable to travel to and fuse with the cell membrane.
As a result, the number of sugar transport channels is reduced leading
to poor cellular sugar absorption and utilization, excess blood
sugar and insulin, low energy and a host of other possible manifestations
of deteriorating health. The product of choice to help increase cell sensitivity is "Glysen" by Apex.
to summarize, insulin resistance results when normal insulin action
is impaired and the cell does not "hear" the message of
the insulin molecule.5 To overcome this impairment, and to maintain
glucose homeostasis, the pancreas will attempt to secrete larger
and larger amounts of insulin. Many individuals will go on to develop
type 2 diabetes, as their compensatory hyperinsulinemia fails and
glucose is no longer controlled.
are an estimated 16 million type-2 diabetics in the U.S. and the
overwhelming majority carries the underlying pathophysiology of
Resistance and Chronic Disease
all individuals who are insulin resistant ultimately develop diabetes;
however, those that do not are at increased risk for hypertension
(HBP), stroke, and coronary heart disease CHD).9 The Insulin Resistance
Syndrome (IRS), also referred to as Syndrome X, refers to a cluster
of symptoms characterized by varying degrees of glucose intolerance,
abnormal high-density lipoprotein (HDL) cholesterol and/or triglyceride's
levels, high blood pressure, and upper body obesity, which are all
independent risk factors for CHD.
Heart Disease (CHD)
indicated, those individuals who maintain the compensatory hyperinsulinemia
in the face of insulin insensitivity do so at great biological cost.
A primary consequence is increased risk for CHD through three mechanisms:
1.) elevated insulin stimulated lipogenesis in arterial tissue and
enhances the growth and proliferation of arterial smooth muscle
cells, contributing to arterioscleroses; 2.) insulin resistance
and hyperinsulinemia decreases fibrinolysis by stimulating plasminogen
activator inhibitor 1 (PAL-1), which is associated with an increased
risk for coronary thrombosis; 10,11 3.) hyperinsulinemia leads to
increased hepatic production of triglyceride's and inhibition of
cystic Ovary Syndrome (PCOS)
resistance also appears to have a critical relationship to androgen
hormonal modulation. Research over the past 10 years has linked
insulin resistance and hyperinsulinemia with PCOS, a prevalent disorder
affecting an estimated 6% of women of reproductive age and the most
common cause of female infertility in the U.S.21
area of increasing research interest is the relationship of insulin
resistance to cancer. One hypothesis has postulated a link between
colorectal cancer, insulin resistance, and hyperinsulinemia. 26-30
Even more recently, speculation has centered on the link between
hyperinsulinemia and breast cancer. 31 It has been known for some
time that exposure of breast tissue to estrogen's increases the
risk of breast cancer. It is well established that only the fraction
of estrogen's unbound to sex hormone binding globulin (SHBG) are
biologically available to receptors on target cells, insulin inhibits
the formation of SHBG. While SHBG binds to both testosterone and
estrogen, it binds preferentially to testosterone, so decreased
levels of SHBG will result in increased levels of free unbound estrogen.
the cellular disturbance is not completely understood at the biochemical
level, modifiable factors such as obesity, exercise, and nutrition
appear to play a significant role. 36-40 While genetic background
may determine propensity to the disorder, these modifiable factors
should be addressed as part of a preventative clinical management
strategy. Although obesity, smoking, and a sedentary lifestyle increase
risk and should be managed aggressively, they are not necessarily
an essential attribute of this disease. Evidence point to the use
of diet and nutritional supplementation as a primary clinical strategy
to manage IRS.
INTERVENTION AN EFFECTIVE APPROACH
a program of regular exercise and effective weight control is important.
Following specific dietary guidelines primarily choosing foods that
have a moderate effect on raising blood sugar, referred to as "low
glycemic index" foods and choosing foods and supplements that
improve the body's ability to support the effect of insulin, functionally
reducing "insulin resistance."
In nutrition many vitamins and nutrients have been sighted as being
a great help to diabetes. By supplementing your diet with a combination
of high macro nutrients that include soy protein,special fibers
and low glycemic starch such as high-amylose starch to help support
healthy carbohydrate absorption and blood sugar metabolism.
your diet with various fatty acids and micro-nutrients may also
be helpful. These include the essential fatty acids EPA and DHA
to support healthy cell membranes; 52 Conjugated Linoleic Acid (CLA)
to support the insulin signal and promote adequate gene expression
for improved utilization of sugar by the mitochondrion, 98 alpha
lipoic acid (ALA) to further support insulin signal and sugar utilization
by the mitochondrion; 99-102 the minerals vanadium, chromium and
magnesium to provide additional support to the insulin signal; vitamin
E and inositol for further insulin signal support; and biotin to
support sugar utilization by the mitochondria. 79-93 The B complex
vitamins have always been utilized in Diabetes as they help convert
food into energy. Zinc is an essential mineral to the pancreas as
it is involved in insulin production. Vanadyl sulfate a recent discovery
has been found to greatly enhance the actions of insulin. It helps
boost insulin's actions and helps to regulate fats. There is a lot
of data available about these nutrients and many others. However
in order to achieve a greater understanding of IRS we must look
all the possible relationships.
Resistance Syndrome is a multi factorial health condition that affects,
by conservative estimates, a quarter of the U.S. population. Loss
of insulin sensitivity appears to be a slow process, and returning
to ability of the cells to optimal functioning may be a gradual
process as well.
and treatment of the underlying biochemical defect, loss of insulin
sensitivity, and resistance to glucose disposal is of central importance,
that is why early detection through effective testing using the
Glucose/Insulin Tolerance Test would be an appropriate place to
to set up a nutritional consultation so these tests can be performed
and a comprehensive strategy of lifestyle, dietary modification
and nutrient supplementation can be implemented to aid you in reversing
an appointment, contact our office at: 800-956-7083 go to lab tests and click
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Rispoli, Ph.D., L Ac. has had a clinical practice for over 20 years.
Her programs work because she is so thorough in testing and providing
a nutritional approach. Remember that the body can heal itself if
given the proper nutrients.
lab tests can be done through the mail in the privacy of your own
home, except blood tests, we send you to a lab to have your blood
drawn for these. After you pay for the test we mail you the kit,
the results take two weeks, the test results will be mailed to us
and we will call you to go over the results, its that easy! All
tests include the consultation for the report of findings.
on area of interest on the left
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you are suffering from unexplained
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